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Diethylstilbestrol (DES)
Veterinary & Aquatic Services Department, Drs. Foster & Smith
Hormones - Endocrine - Reproduction
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Diethylstilbestrol is a type of estrogen. It is used for the treatment of urinary incontinence in dogs. It may also be used to treat prostate hypertrophy (enlargement), certain types of cancers, and reproductive conditions. Most dogs being treated with DES for urinary incontinence need to be treated long term, but some dogs may need to be treated seasonally or for several months. Side effects are less common with dosages used to treat estrogen responsive urinary incontinence. At higher doses or long-term use, contact your veterinarian if your pet experiences signs of estrus (female dog coming into heat), feminization in males, lack of appetite, vomiting, diarrhea, vaginal discharge, pyometra (infection in the uterus), lethargy, increased thirst or urination, bruising, bleeding, or anemia while being treated with DES. Prolonged use may cause ovarian cancer. Prolonged use in cats may cause damage to the heart, liver, and pancreas. CAUTION: Pregnant women, or women trying to become pregnant, should avoid contact with DES or any estrogen-containing drug.


Keep this and all other medications out of the reach of children and pets.


If you think your pet has been poisoned...

Contact your veterinarian or one of the Animal Poison Hotlines (listed below) if you think your pet may have accidentally received or been given an overdose of the medication.

**ASPCA Animal Poison Control Center - 24-hour service available throughout North America.
www.aspca.org/apcc

1-888-4ANI-HELP (1-888-426-4435). $65.00 per case, billed to caller's credit card.

Follow-up calls can be made for no additional charge by dialing 888-299-2973.

There is no charge when the call involves a product covered by the Animal Product Safety Service.

**Pet Poison Helpline - 24-hour service available throughout North America for pet owners and veterinary professionals who require assistance with treating a potentially poisoned pet.

1-800-213-6680 ($59.00 per incident). Staffed 24-hours a day.

Updated 6/20/17


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