Type of Drug
Antihistamine and antiemetic
Form and Storage
Tablet and liquid
Store at room temperature in a tightly closed container.
Indications for Use
Used to decrease motion sickness in dogs. Can be used in cats, but better choices are available.
Not FDA approved for use in veterinary medicine, but it is a common and accepted practice to use dimenhydrinate in dogs and cats. Available over the counter. Dimenhydrinate blocks the input to the brain from the vestibular system (inner ear and balance). Effectiveness for sedation and motion sickness relief may decrease over time.
May see sedation, dry mouth, and inability to fully empty the bladder. Diarrhea, vomiting, and loss of appetite are less commonly seen.
Do not use in patients who are hypersensitive (allergic) to it or other antihistamines.
Do not use in patients with certain types of glaucoma, prostate disease, stomach or intestinal obstruction, urinary obstruction, certain heart and lung diseases, hyperthyroidism, seizures, or high blood pressure.
Working dogs may be affected by the sedative effect.
May mask symptoms of ear problems.
Not for use in pregnant or nursing animals.
Stop use at least 4 days prior to skin allergy testing.
Drug or Food Interactions
Increased effects if used with other central nervous system (CNS) depressants or anticholinergic drugs.
May increase the effect of epinephrine. May decrease the effect of anticoagulants.
May have fewer side effects if given with food.
May see excitement or seizures, lethargy, or coma,
respiratory depression, or death.