Generic Name
Mibolerone

Brand Name
Cheque Drops

Type of Drug
Androgenic steroid

Form and Storage
Drops
Store at room temperature unless otherwise specified by the manufacturer.

Indication for Use
Prevention of estrus, infertility, false pregnancy

General Information
FDA approved for use in dogs for estrus suppression. Mibolerone is an androgenic steroid which opposes the effects of estrogen and other hormones which cause ovulation and subsequent production of progesterone. Need to start the medication at least 30 days before proestrus to prevent the female from coming into heat. It is about 90% effective. Do not use in dogs which are to be bred in the future, as start of the next cycle may vary from 7-200 days from discontinuation of Cheque Drops. It has been used to lengthen short cycles which cause infertility and to treat false pregnancies. The false pregnancy may recur when the medication is discontinued. Because of this and the fact that most false pregnancies resolve on their own, no treatment is usually given. The most effective way to prevent these problems in dogs who are not showing in the breed ring and are not going to be used for breeding is by an ovariohysterectomy (spay).

Usual Dose and Administration
Contact your veterinarian.

Side Effects
May see increase in clitoral size which may resolve after treatment is discontinued, vaginal discharge, mounting other dogs, aggression, change in voice, increase in oily skin and body odor, reproductive tract lesions, tearing, or urinary incontinence. May also cause liver disease or death especially in cats.

Contraindications/Warnings
Do not use in Bedlington Terriers or other breeds predisposed to kidney or liver disease.

Do not use in patients with liver or kidney disease.

Do not use in patients with androgen-dependent cancers such as perianal adenocarcinomas (malignant tumors that occur near the anus).

Do not use before the first estrus cycle, in pregnant or nursing dogs, or for more than 24 months.

Do not use in cats, as it has a very narrow therapeutic range.

Drug or Food Interactions
Do not use with progestins or estrogens.

May decrease effect of phenytoin.

No known food interactions.

Overdose/Toxicity
May see increased tearing, lethargy, lack of appetite, weight loss, muscle pain, or liver, pancreatic, or thyroid disease. May cause death.