Nonsteroidal Anti-inflammatory Drugs
Many analgesics, fever medications, and anti-inflammatory medications such as ibuprofen (Motrin, Advil, Nuprin, Vick's DayQuil), indomethacin, piroxicam (Feldene), phenylbutazone (Bute and Butazolidin), and naproxen (Naprosyn and Aleve). Veterinary NSAIDs include products such as aspirin, carprofen (Rimadyl), ketoprofen, deracoxib (Deramaxx), meloxicam (Metacam), tepoxalin (Zubrin), and etodolac (EtoGesic).
Always check with your veterinarian before giving any medication to your pet. Many medications available for human use are dangerous to pets. The NSAIDs are an example of this, especially in cats. NSAIDs decrease production of substances that protect the stomach and GI tract from the acid and reduce blood flow to the area. This can cause ulceration and perforation of the stomach or intestines. NSAIDs also decrease the blood flow to the kidneys causing damage and renal failure. Phenylbutazone may also cause liver damage.
Varies with each medication and species.
Example: Ibuprofen is toxic at 22-50 mg per pound of body weight.
Abdominal pain, anemia, blood in the stool (blood may be digested so the stool appears black and tarry), vomiting with or without blood, lethargy, ataxia, stupor, and shock if perforation has occurred.
Induce vomiting. Seek veterinary attention.
General treatment: The induction of vomiting may be continued, gastric lavage is performed, and activated charcoal is administered.
Supportive treatment: IV fluids are administered to try to protect the kidneys and treat for shock. Medications such as Sucralfate and misoprostol are administered in an effort to try to prevent formation of gastric ulcers. Repeated blood tests will be performed to monitor the function of kidneys and liver.
Specific treatment: Unavailable.
Guarded to poor.