Pet Education Small Pets
Pet Education Small Pets Pet Education Small Pets Pet Education Small Pets
Free Shipping on orders over $49
Chronic Progressive Nephrosis: A Common Kidney Disease
Veterinary & Aquatic Services Department, Drs. Foster & Smith
Print Article | Email Article
Bookmark and Share
Click here for a pdf version of this article.  See related products at DrsFosterSmith.com Pet Supplies

Older rats are commonly affected by a kidney disease called Chronic Progressive Nephrosis.

What is Chronic Progressive Nephrosis?

Chronic Progressive Nephrosis is a non-infectious disease of the kidneys in rats, and is age-related. "Chronic" means it is ongoing; "Progressive" means it steadily gets worse; and "Nephropathy" is the term for disease of the kidneys.

Which rats are at risk for Chronic Progressive Nephrosis?

This disease affects older rats, and is usually more severe and may occur earlier in males. The incidence in males is reduced if they are castrated. Sprague-Dawley rats are often affected earlier in life. Rats that are fed high-protein diets are at higher risk of developing this disease. Certain chemicals can increase the severity of the disease.

What are the signs of Chronic Progressive Nephrosis?

Rats with Chronic Progressive Nephrosis often show a chronic loss of weight, become inactive, and may have rough hair coats. They may produce more urine than normal rats. The major laboratory finding is a great increase of protein, mostly albumin, in the urine. The amount of albumin present correlates with the degree of kidney disease, i.e.; the higher the albumin, the worse the disease. The kidneys are enlarged and pale and have a pitted appearance.

What is the treatment for Chronic Progressive Nephrosis?

Rats with this disease need to be fed diets low in protein. Feeding soybean protein (versus protein from other sources) and limiting calories will reduce the severity of the disease, and may help prevent it. Rats with Chronic Progressive Nephrosis may also be treated with anabolic steroids.

 
References and Further Reading

Anderson, NL. Basic husbandry and medicine of pocket pets. Birchard, SJ; Sherding, RG. eds. Saunders Manual of Small Animal Practice. W.B. Saunders Co. Philadelphia, PA; 1994.

Bold, JB. Diseases and neoplasms of the aging rat. Presented at the 46TH Annual Pathology of Laboratory Animals Course, AFIP. August 1999.

Donnelly, TM. Disease problems of small rodents. In Quesenberry, KE; Carpenter, JW. eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery. W.B. Saunders Co. Philadelphia, PA; 2004.

Thudium, D; Adams, D; Sellers, T; Rehm, S; Ennulat, D; Schwartz, L. Urinary albumin as a sensitive marker for nephropathy in aged male rats. Presented at the American Society for Veterinary Clinical Pathology Scientific Session II, December 2001.

Click here for a pdf version of this article.  See related products at DrsFosterSmith.com Pet Supplies  
Print Article | Email Article
 
 
Stainless Steel Cage Cups
Stainless Steel Cage Cups
As low as $1.99
 
Wide-Mouth Water Bottles
Wide-Mouth Water Bottles
As low as $2.99
 
Glass Eco Water Bottle
Glass Eco Water Bottle
As low as $4.49
 
Hay Feeder
Hay Feeder
As low as $5.99
 

Facebook YouTube Blog Connect with us

Subscribe to email newsletters:
featuring helpful articles, tips and online only product specials from Drs. Foster & Smith. Learn more here !

About Us Article Reprints Awards & Memberships Request a FREE Catalog Tell a Friend
Meet Our Staff Terms & Use Site Map Free Newsletters Links to Us
Visit our other websites: Doctors Foster and Smith Pet Supplies LiveAquaria.com - Quality Aquatic Life Direct to Your Door
For product information, call 1-800-826-7206

Copyright © 1997-2013, Foster and Smith, Inc. - 2253 Air Park Road, P.O. Box 100, Rhinelander, Wisconsin, 54501. All rights reserved.