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Chemotherapy: Drugs Used to Treat Cancer
Veterinary & Aquatic Services Department, Drs. Foster & Smith
Cancer and Tumors
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Drugs are often used to treat cancer in dogs and cats.

How do anti-cancer drugs work?
Chemotherapy works by killing cells that are actively dividing (growing and making new cells). This is an important characteristic of cancer cells. Other actively dividing cells normally found in the body include those in the bone marrow, hair follicles and the lining of the stomach and intestines. That is why side effects usually involve these cells.

How is the best chemotherapy determined?
Many different regimens are used in the treatment of cancer in dogs and cats. The choice of which drug(s) to use is based on multiple factors including:

  • The species of pet
  • Health status of the pet
  • The type of cancer
  • Stage of the cancer

Many times, multiple drugs are used in combination to treat the cancer. This can increase their effectiveness and decrease the number and/or severity of side effects of the drugs.

How is chemotherapy given to pets?
Most anti-cancer drugs are given by injection into the vein (intravenous). This must be done with extreme care to avoid getting any of the medication outside of the vein, where it can be very irritating to the tissues. A few anti-cancer drugs are available in oral forms.

Because of the potential toxicity of the drugs, all anti-cancer medications must be handled very carefully. Your veterinarian and the clinic staff will need to take safety precautions when preparing these medications for use and providing the therapy to your cat or dog. Depending on the drug, these can include wearing protective clothes, gloves, masks, and goggles. With proper safety precautions, some of the oral forms of chemotherapy can be given at home.

What are some of the common drugs used in chemotherapy in dogs and cats?
The following table lists the more common drugs used in the treatment of cancer in dogs and cats.

Drug Effective Against Administration Side Effects
Carboplatin Carcinoma
Sarcoma (especially osteosarcoma in dogs)
Intravenous Bone marrow suppression
Loss of appetite and vomiting in small dogs
Chlorambucil
(Leukeran)
Chronic lymphoid leukemia
Low grade lymphoma
Oral Seizures
Bone marrow suppression
Liver toxicity (uncommon)
Cyclophosphamide
(Cytoxan)
Lymphoma
Some sarcomas
Some carcinomas
Intravenous or
Oral
Bone marrow suppression
Severe inflammation of the bladder (hemorrhagic cystitis)
Doxoribicin
(Adriamycin)
Lymphoma (dogs)
Some sarcomas
Intravenous Bone marrow suppression
Locally irritating
Vomiting
Heart toxicity
Kidney toxicity (cats)
L-asparaginase Lymphoma (especially dogs) Subcutaneous or intramuscular
injection
Allergic reaction
Vomiting
Bone marrow suppression if given with vincristine
Lomustine (CCNU) Lymphoma
Mast cell tumors
Histiocytic sarcoma
Some brain tumors
Oral Bone marrow suppression
Liver toxicity
Kidney toxicity (uncommon)
Mitoxantrone
(Novantrone)
Lymphoma (dogs)
Some carcinomas (dogs)
Intravenous Bone marrow suppression
Colitis (can be severe)
Vinblastine
(Velban)
Lymphoma
Mast cell tumors (dogs)
Intravenous Bone marrow suppression
Vincristine
(Oncovin)
Lymphoma
Venereal tumors (dogs)
Some sarcomas
Intravenous Bone marrow suppression if used with L-asparaginase
Loss of appetite
Nervous system toxicity (rare)
-table adapted from: Moore, A. Commonly used chemotherapy drugs, Part 1. NAVC Clinician's Brief. October 2010.


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