Product	Active Ingredient	Species & Minimum Age	Dosage & Administration	Effects on External Parasites	Comments
For Use on Pets
Advantage II for Cats	Imidacloprid Pyriproxyfen	For cats 8+ weeks	Topical: Once/month	Kills adult fleas, eggs and larvae. Does not kill ticks.	Consult with veterinarian before using on sick, aged, pregnant, or nursing animals.
Advantage II for Dogs	Imidacloprid Pyriproxyfen	For dogs 7+ weeks	Topical: Once/month	Kills lice and adult fleas, eggs and larvae. Does not kill ticks.	Consult with veterinarian before using on sick, aged, pregnant, or nursing animals.
Advantage Multi for Cats	Imidacloprid Moxidectin	For cats 9+ weeks and 2+ lbs	Topical: Once/month	Kills adult fleas and ear mites. Does not kill ticks.	Prevents heartworm; treats and controls roundworms and hookworms. Consult with veterinarian before using on sick, aged, pregnant, or nursing animals.
Advantage Multi for Dogs	Imidacloprid Moxidectin	For dogs 7+ weeks and 3+ lbs Do NOT use on cats.	Topical: Once/month	Kills adult fleas. Does not kill ticks.	Prevents heartworm; treats and controls roundworms, whipworms and hookworms. Consult with veterinarian before using on sick, aged, pregnant, or nursing animals. Do NOT use on cats.
K9 Advantix II for Dogs	Imidacloprid Permethrin Pyriproxyfen	For dogs 7+ weeks Do NOT use on cats.	Topical: Once/month	Kills flea eggs and larvae. Kills and repels fleas, ticks and mosquitoes. Repels biting flies. Kills lice.	Consult with veterinarian before using on sick, aged, pregnant, or nursing dogs. Do NOT use on cats.
Bio Spot Flea and Tick Spray for Cats and Kittens	Pyrethrin Methoprene	For cats 12+ weeks	Topical: Spray once every 2 months	Kills and repels adult fleas and ticks; kills flea eggs.	Consult with veterinarian before using on sick, medicated, aged, pregnant, or nursing cats.
Bio Spot Defense Flea and Tick Spray for Cats and Kittens	Etofenprox Methoprene	For cats 12+ weeks	Topical: Spray once every month; may be reapplied two weeks after initial application.	Kills and repels adult fleas and ticks; kills flea eggs.	Consult with veterinarian before using on sick, medicated, aged, pregnant, or nursing cats.
Bio Spot-Spot On for Cats and Kittens	Etofenprox Methoprene	For cats 12+ weeks	Topical: Once/month	Kills flea eggs and adult fleas and deer ticks; kills and repels mosquitoes.	Consult with veterinarian before using on sick, medicated, aged, pregnant, or nursing cats.
Bio Spot Defense Spot On Flea and Tick Control for Dogs	Etofenprox Methoprene	For dogs 6 months or older	Topical: Once/month	Kills adult fleas and ticks; stops development of flea eggs. Kills and repels mosquitoes.	Consult with veterinarian before using on sick, medicated, aged, pregnant, or nursing dogs. Do NOT use on cats.
Bio Spot Defense Flea and Tick Spray for Dogs and Puppies	Etofenprox Methoprene	For dogs 10+ weeks	Topical: Spray once every month; may be reapplied two weeks after initial application.	Kills and repels adult fleas and ticks; kills flea eggs.	Consult with veterinarian before using on sick, medicated, aged, pregnant, or nursing dogs. Do NOT use on cats.
Capstar	Nitenpyram	For dogs and cats 4+ weeks, and 2+ lbs	Oral: As needed (can be given daily)	Kills adult fleas. Starts to work in 30 minutes; no residual activity.	Can be used with other flea products.
Certifect for Dogs	Fipronil Methoprene Amitraz	For dogs 8+ weeks and over 5 lbs	Topical: Once/month	Kills adult fleas, ticks, and chewing lice.	Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals. Do NOT use on cats.
Comfortis for Dogs	Spinosad	For dogs 14+ weeks	Oral: Once/month	Kills adult fleas.	Caution in breeding females and those with epilepsy.
Fiproguard for Cats	Fipronil	For cats 8+ weeks	Topical: Once/month	Kills adult fleas and ticks and chewing lice.	Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.
Fiproguard Max for Cats	Fipronil Etofenprox	For cats 12+ weeks	Topical: Once/month	Kills adult fleas and ticks and chewing lice.	Consult with veterinarian before using on sick, medicated or aged animals.
Fiproguard for Dogs	Fipronil	For dogs 8+ weeks	Topical: Once/month	Kills adult fleas, ticks, and chewing lice. Aids in the control of sarcoptic mange.	Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.
Fiproguard Max for Dogs	Fipronil Cyphenothrin	For dogs 12+ weeks	Topical: Once/month	Kills adult fleas, ticks, and chewing lice. Aids in the control of sarcoptic mange.	Consult with veterinarian before using on sick, medicated or aged animals.
Frontline Plus for Cats	Fipronil Methoprene	For cats 8+ weeks	Topical: Once/month	Kills adult fleas and ticks. Prevents flea eggs, larvae and pupae from maturing. Treats and controls chewing lice.	Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.
Frontline Plus for Dogs	Fipronil Methoprene	For dogs 8+ weeks	Topical: Once/month	Kills adult fleas and ticks. Prevents flea eggs, larvae and pupae from maturing. Treats and controls chewing lice. Aids in the control of sarcoptic mange.	Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.
Frontline Spray for Cats and Dogs	Fipronil	For dogs 8+ weeks and cats 8+ weeks	Topical spray: Once/month	Kills adult fleas, ticks, and chewing lice. Aids in control of sarcoptic mange in dogs.	Consult with veterinarian before using on sick, medicated, aged, pregnant, or nursing animals.
Frontline Top Spot for Cats and Kittens	Fipronil	For cats 8+ weeks	Topical: Once/month	Kills adult fleas, ticks, and chewing lice.	Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.
Frontline Top Spot for Dogs and Puppies	Fipronil	For dogs 8+ weeks	Topical: Once/month	Kills adult fleas, ticks, and chewing lice. Aids in the control of sarcoptic mange.	Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.
PetArmor for Cats	Fipronil	For cats 8+ weeks	Topical: Once/month	Kills adult fleas and ticks and chewing lice.	Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.
PetArmor for Dogs	Fipronil	For dogs 8+ weeks	Topical: Once/month	Kills adult fleas, ticks, and chewing lice. Aids in the control of sarcoptic mange.	Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.
Preventic Tick Collar for Dogs	Amitraz	For dogs 12+ weeks Do NOT use on cats.	Collar: Once/3 months	Kills ticks.	Consult with veterinarian before using on sick, medicated, aged, pregnant, or nursing dogs. Do NOT use on cats.
Program Injectable for Cats	Lufenuron (IDI)	For cats 6+ weeks	Once/6 months.	Stops the development of flea eggs. Does not kill adult fleas. Does not kill ticks.	Consult with veterinarian before using on sick, medicated, aged, pregnant, or nursing animals.
Program Flavor Tabs for Dogs and Cats	Lufenuron (IDI)	For dogs 4+ weeks and cats 4+ weeks	Once/month	Stops the development of flea eggs. Does not kill adult fleas. Does not kill ticks.	Consult with veterinarian before using on sick, medicated, aged, pregnant, or nursing animals.
Program Suspension for Cats	Lufenuron (IDI)	For cats 6+ weeks	Once/month	Stops the development of flea eggs. Does not kill adult fleas. Does not kill ticks.	Consult with veterinarian before using on sick, medicated, aged, pregnant, or nursing animals.
Revolution	Selamectin	For dogs 6+ weeks and cats 8+ weeks	Topical liquid: Once/month	Kills adult fleas, flea eggs, and American dog tick; treats and controls ear mites, controls sarcoptic mites (dogs).	Prevents heartworms; controls roundworms and hookworms (cats). Appears to be safe to use in pregnant or nursing dogs and cats. Use with caution on sick, medicated or underweight animals.
Scalibor for Dogs	Deltamethrin	For dogs 12+ weeks	Collar	Kills adult fleas and ticks.	Consult with veterinarian before using on sick, aged, pregnant, or nursing animals. Available through veterinarians only.
Sentinel Flavor Tabs for Dogs	Lufenuron (IDI), Milbemycin Oxime	For dogs 4+ weeks, and 2+ lbs	Oral tablet: Once/month	Stops development of flea eggs and larvae. Does not kill ticks or adult fleas.	Prevents heartworms; controls roundworms, whipworms and hookworms. Safe to use in pregnant or nursing dogs.
Trifexis for Dogs	Spinosad Milbemycin Oxime	For dogs 8+ weeks, and 5+ lbs	Oral tablet: Once/month	Kills adult fleas	Prevents heartworms; treats and controls hookworms, roundworms and whipworms. Use with caution in dogs with epilepsy and breeding dogs.
Vectra for Cats and Kittens	Dinotefuran Pyriproxifen	For cats 8+weeks	Topical liquid: Once/month	Kills adult fleas; controls all flea stages	Consult with veterinarian before using on sick, aged, pregnant, or nursing animals. Available through veterinarians only.
Vectra for Dogs and Puppies	Dinotefuran Pyriproxifen	For dogs 8+ weeks	Topical liquid: Once/month	Kills adult fleas; controls all flea stages	Consult with veterinarian before using on sick, aged, pregnant, or nursing animals. Do NOT use on cats. Available through veterinarians only.
Vectra 3D for Dogs	Permethrin Dinotefuran Pyriproxifen	For dogs 7+ weeks Do NOT use on cats	Topical liquid: Once/month	Repels and kills fleas, ticks, mosquitos, lice, sand flies, and mites; controls all flea stages	Consult with veterinarian before using on sick, aged, pregnant, or nursing animals. Do NOT use on cats. Available through veterinarians only.