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Drugs That May Or May Not Be Used in Pregnant Dogs
Veterinary & Aquatic Services Department, Drs. Foster & Smith
Hormones - Endocrine - Reproduction
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With a few exceptions as noted below, one should avoid using all medications in pregnant and lactating (nursing) dogs. There may be instances in which a medication not recommended for use during pregnancy may need to be used to save the life of the bitch, even though it may potentially harm the fetuses. Always consult with your veterinarian before administering any drug or supplement to a pregnant or nursing dog.

NOTE: This is only a partial listing of drugs that should be avoided in pregnant or nursing dogs. A listing of all such drugs is beyond the scope of this article. If you have concerns regarding a specific drug, type it in the search box above.

Drug May Be Used Do Not Use Safety Studies in Dogs Not Available; Consult Your Veterinarian
Acemannan   x  
Acepromazine   x  
Acetylcysteine Use as an antidote, only.    
Activated Charcoal x    
Albuterol   x  
Allopurinol   x  
Amikacin   x  
Aminopenicillins (Amoxicillin, Ampicillin)     x
Aminopentamide (Centrine)     x
Amitraz (Mitaban, Preventic Collars)   x  
Amitriptyline (Elavil)   x  
Antacids (Maalox, Milk of Magnesia)   x  
Artificial Tears x    
Aspirin   x  
Atropine Eye Medication x    
Azathioprine (Imuran)   x  
Bismuth Subsalicylate (Pepto Bismol)   x  
Buspirone (Buspar)   x  
Butorphanol (Torbutrol, Torbugesic)   x  
Carprofen (Rimadyl)   x  
Cephalosporins (Keflex, Cefa-drops)     x
Chlorpheniramine (Chlor-Trimeton)   x  
Cimetidine (Tagamet)   x  
Cisapride (Propulsid)   x  
Clemastine (Tavist 1)   x  
Clindamycin (Antirobe)     Use with caution.
Clomipramine (Clomicalm, Anafranil)   x  
Cyclosporin (Optimmune)     x
Cyproheptadine   x  
Dextromethorphan   x  
Diazepam (Valium)   x  
Digoxin (Cardoxin)     Give only if clearly needed.
Dimenhydrinate (Dramamine)   x  
Diphenhydramine (Benadryl)   x  
DMSO (Synotic)   x  
DOCP   x  
Enalapril (Enacard, Vasotec)   x  
Enrofloxacin (Baytril)   x  
Epsiprantel (Cestex)   x  
Erythromycin   x  
Erythropoietin (EPO, Epogen)   x  
Estrogens (ECP, DES)   x  
Etodolac (EtoGesic)   x  
Extended Spectrum Penicillins (Carbenicillin)   x  
Famotidine (Pepcid)   x  
Fatty acids     Not recommended for pregnant humans.
Fenbendazole (Panacur) x    
Fentanyl   x  
Fipronil (Frontline)
  Frontline Plus
  Frontline Top Spot
  Frontline Spray
Fludrocortisone (Florinef)   x  
Fluoxetine (Prozac)   x  
Furosemide (Lasix)   x  
Gentamicin (Gentocin)   x  
Glucocorticosteroids (Prednisone, Dexamethasone, Hydrocortisone)   x  
Glycosaminoglycans (Glucosamine, Chondroitin)     x
Griseofulvin (Fulvicin)   x  
Hydroxyzine (Atarax)   x  
Imidacloprid (Advantage)   x  
Insulin x   Note: Diabetic dogs should not be bred.
Itraconazole (Sporanox)   x  
Ivermectin (Heartgard) x    
Kanamycin (Amforal, Kantrim)   x  
Kaolin (Kaopectate, Canine Pectate)
**See Note Below
Loperamide (Immodium)   x  
Lufenuron (Program) x    
Mannitol   x  
Marbofloxacin (Zeniquin)   x  
Mebendazole (Telmintic)   x  
Meclofenamic Acid (Arquel)   x  
Melarsomine (Immiticide)   x  
Methimazole (Tapazole)   x  
Methionine (Methigel, Methio-Form)   x  
Metoclopramide (Reglan)     x
Metronidazole (Flagyl)   x  
Mibolerone (Cheque Drops)   x  
Milbemycin (Interceptor, Sentinel) x    
Misoprostol (Cytotec)   x  
Mitotane (o,p-DDD, Lysodren)   x  
Natural Penicillins (Penicillin G, Crystiben, Penicillin V)   x  
Neomycin   x  
Novobiocin (Albaplex)   x  
Omeprazole (Prilosec)   x  
Orbifloxacin (Orbax)   x  
Oxytocin (Pitocin) At delivery.    
Pancreatic Enzymes (Pancrezyme, Viokase-K) x    
Penicillinase Resistant Penicillins (Cloxacillin)   x  
Pentobarbital   x  
Permethrin (Bio Spot-Spot On for Dogs, K9 Advantix)     x
Phenobarbital   x  
Phenylbutazone   x  
Phenylpropanolamine (Dexatrim)   x  
Phenytoin (Dilantin)   x  
Phytonadione (Vitamin K)   x  
Piperazine (Happy Jack Kennel Wormer, Purina Liquid Wormer, Sergeants Worm Away, Pipa Tabs, Piper Worm Wormer) Other wormers are preferred.    
Polysulfated Glycosaminoglycan (Adequan)   x  
Potassium Depends on type & reason for use.    
Potassium Bromide   x  
Potentiated Penicillins (Clavamox, Augmentin)   x  
Primidone   x  
Psyllium (Metamucil, Vetasyl) x    
Pyrantel Pamoate (ProWormer-2, Nemex) Do not use wormers with additional ingredients.    
Ranitidine (Zantac)   x  
Rotenone (Goodwinol Ointment) x   Caution: Do not use on puppies, or expose puppies to this medication.
Selamectin (Revolution) x    
Selegiline (Anipryl)   x  
Sucralfate     x
Sulfadimethoxine (Albon, Bactrovet)   x  
Sulfadimethoxine & Ormetroprim (Primor)   x  
Terbutaline   x  
Tetracyclines (Doxycycline, Oxytetracycline)   x  
Theophylline (Theo-Dur)   x  
Thiacetarsamide (Caparsolate)     Use with caution.
Thyroxine (Synthroid, Soloxine) x   Note: Hypothyroid dogs should not be bred.
Trimeprazine (Temaril-P)   x  
Trimethoprim & Sulfadiazine (Tribrissen)   x  

**CAUTION: Some Kaopectate includes bismuth salicylate as an ingredient. Dogs that may have an allergy to aspirin, or are taking aspirin, steroids, or another non-steroidal anti-inflammatory drug (NSAID) such as Rimadyl, EtoGesic, or Deramaxx should not be given the formulation with bismuth salicylate unless directed by a veterinarian.

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