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Moxidectin (Advantage Multi®, ProHeart® 6)
Veterinary & Aquatic Services Department, Drs. Foster & Smith
Wormers & Anti-parasitics
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Summary

Moxidectin is a heartworm preventive for dogs, cats and ferrets. In the formulation, Advantage Multi, it is combined with imidacloprid and is used topically once a month. ProHeart 6 is an injectable formulation for use in dogs only.

Generic Name
Moxidectin

Brand Names
Advantage Multi
ProHeart 6

Type of Drug
Heartworm preventive, anthelmintic/dewormer, ectoparasiticide (kills external parasites)

Form and Storage
Advantage Multi is a topical medication. Store at room temperature. Protect from light.

ProHeart 6 is an injectable medication available only through veterinarians.

Indications for Use
Advantage Multi is indicated for the prevention of heartworm disease in dogs, cats and ferrets; treatment of certain intestinal parasite infestations in dogs and cats, treats and controls ear mites in cats, and kills fleas in dogs, cats and ferrets.

ProHeart 6 is indicated for the prevention of heartworm disease and the treatment of hookworms in dogs.

General Information
Advantage Multi is FDA approved for flea control and prevention, killing adult fleas and larvae. It does not kill ticks. It prevents heartworm and treats infestations with roundworms (dogs and cats), hookworms (dogs and cats), and whipworms (dogs only). It also treats and controls ear mites in cats. Consult with veterinarian before using on sick, aged, pregnant, or nursing animals.

ProHeart 6 is FDA approved for the prevention of heartworm disease and the treatment of hookworm infestations in dogs 6 months of age and older. ProHeart 6 should not be given to dogs that are sick, debilitated, underweight, or have a history of weight loss.

Usual Dose and Administration
Advantage Multi is administered topically once a month.

ProHeart 6 is administered via an injection every 6 months.

Side Effects
May see transient, localized inflammation at injection site (ProHeart 6), irritation at the application site (Advantage Multi), vomiting, diarrhea, listlessness, weight loss, seizures, injection site pruritis, and elevated body temperature.

Contraindications/Warnings
Not for use in animals that are hypersensitive (allergic) to it.

Dermal adverse effects have included application site reactions. Oral ingestion (licking or dosing) has shown drooling, vomiting, diarrhea and tremors in some animals.

Not tested for use in dogs less than 6 months of age.

Do not use more often than every 6 months.

A heartworm test should be performed before treating with ProHeart 6 as it is not effective against adult heartworms or microfilariae.

Considered to be safe to use in pregnant and lactating females, breeding males, and ivermectin-sensitive collies.

Use with caution in sick, debilitated, or underweight dogs.

Drug or Food Interactions
None known.

Overdose/Toxicity
May see swelling/edema at injection site. May see weight loss.

Special Note
Hookworms are zoonotic, meaning they can infect humans. Cutaneous larval migrans is caused by hookworm larvae that penetrate the skin of people who come into contact with moist soil harboring the hookworm larvae. In humans, the parasites usually die in the skin leaving a reaction of redness, irritation, and itching. Prevention includes annual stool testing/deworming of pets, wearing shoes outside, and wearing gloves when gardening. Consult your veterinarian and physician for more information.

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