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S-Adenosylmethionine (Denosyl® SD-4)
Veterinary & Aquatic Services Department, Drs. Foster & Smith
Digestive Tract, Liver, & Pancreas
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S-adenosylmethionine (SAMe) is a substance normally produced by the body from the amino acid methionine. It is necessary for the production of glutathione, a powerful antioxidant, by the liver. Supplemental SAMe has been recommended for dogs, cats, and other pets with various forms of liver disease. It may also be useful in pets receiving long-term treatments for diseases such as epilepsy, in which the medication used is metabolized by the liver. SAMe is generally very safe, but can cause irritation of the throat and esophagus if it is not quickly swallowed and moved to the stomach. This is especially true for cats. For this reason, give your pet a small amount (one teaspoon) of water after giving the SAMe to help your pet swallow.


Keep this and all other medications out of the reach of children and pets.


If you think your pet has been poisoned...

Contact your veterinarian or one of the Animal Poison Hotlines (listed below) if you think your pet may have accidentally received or been given an overdose of the medication.

**ASPCA Animal Poison Control Center - 24-hour service available throughout North America.
www.aspca.org/apcc

1-888-4ANI-HELP (1-888-426-4435). $65.00 per case, billed to caller's credit card.

Follow-up calls can be made for no additional charge by dialing 888-299-2973.

There is no charge when the call involves a product covered by the Animal Product Safety Service.

**Pet Poison Helpline - 24-hour service available throughout North America for pet owners and veterinary professionals who require assistance with treating a potentially poisoned pet.

1-800-213-6680 ($59.00 per incident). Staffed 24-hours a day.

Updated 6/20/17


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