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Length of Time it Takes for a Vaccine to Provide Protection
Veterinary & Aquatic Services Department, Drs. Foster & Smith
FAQ's on Vaccines
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Q. How long does it take for a vaccine to work?
 
A. Vaccines do not stimulate immunity immediately after they are administered. Once a vaccine is administered, the antigens must be recognized, responded to, and remembered by the immune system. In most animals, disease protection does not begin until five days after vaccination. Full protection from a vaccine usually takes up to fourteen days. In some instances, two or more vaccinations several weeks apart must be given to achieve protection. In general, modified live vaccines and those vaccines administered intranasally provide the fastest protection.

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